Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults
نویسندگان
چکیده
منابع مشابه
Colestimide reduces blood polychlorinated biphenyl (PCB) levels.
1. A: Blood level of PCBs before and after the treatment in nine subjects. Closed circles show blood PCB level of each subject. Open circles show the mean blood level of PCB. B: Correlation between initial PCB concentration and reduction ratio (%) of PCB after colestimide treatment. (R= 0.64) C: Correlation of alteration in PCB and dioxin level after colestimide treatment. Data expresses the pe...
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The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...
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Polychlorinated biphenyls (PCBs) are a widespread class of persistent organic chemicals that accumulate in the environment and humans and are associated with a broad spectrum of health effects. PCB biotransformation has been shown to lead to two classes of PCB metabolites that are present as contaminant residues in the tissues of selected biota: hydroxylated (HO) and methyl sulfone (MeSO2) PCBs...
متن کاملCleaning Polychlorinated Biphenyl (PCB) Contaminated Garden Soil by Phytoremediation.
A poplar planted system resulted in the complete removal of at least 19 of the 29 potential polychlorinated biphenyl (PCB) congeners detected in trace amounts (37.9 ng g-1 in total) in a commercial garden soil, while the unplanted soil only had 2 congeners completely removed after 96 days. In addition, the most recalcitrant congener, PCB 52, only decreased by 0.1% in the unplanted reactors whil...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2007
ISSN: 0041-008X
DOI: 10.1016/j.taap.2007.07.002